Modeling Backbone Flexibility Improves Protein Stability Estimation
نویسندگان
چکیده
منابع مشابه
Modeling backbone flexibility improves protein stability estimation.
In designing mutagenesis experiments, it is often crucial to know how certain mutations will affect the structure and thermodynamic stability of the protein. Here, we present a methodology, Eris, to efficiently and accurately compute the stability changes of proteins upon mutations using our protein-modeling suite, Medusa. We evaluate the stability changes upon mutations for 595 mutants from fi...
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ژورنال
عنوان ژورنال: Structure
سال: 2007
ISSN: 0969-2126
DOI: 10.1016/j.str.2007.09.024